The theory of midnight-noon ebb-flow is a part of chronomedicine of Chinese medicine.It divides a 24-hour day into twelve two-hour periods,each corresponding to the qi and blood circulation of the twelve zang-fu organs in human body,reflecting the circadian rhythm.Both physiological and pathological fluctuations of intraocular pressure in glaucoma patients are related to the functions of zang-fu organs and meridians.The mechanism underlying the diurnal fluctuation in intraocular pressure involves multifactorial regulation,including the biological clock,melatonin levels,and the function of intrinsic photosensitive retinal ganglion cells.By analyzing the correlation between the theory of midnight-noon ebb-flow and the circadian rhythm,this article explores the effects of circadian rhythm on intraocular pressure rhythm disruption in glaucoma.It further proposes new strategies for treating glaucoma with Chinese medicine,providing novel perspectives and approaches for the clinical treatment of glaucoma.
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