Alzheimer's disease(AD)is a central neurodegenerative disease with an unknown etiology.Recent studies have indicated a strong correlation between the development and progression of AD and the abundance or diversity of oral and intestinal flora.Increasing evidence suggests that Chinese medicines may indirectly prevent and treat AD by influencing microbiota metabolism.To further explore the mechanism of action by which Chinese medicines prevent and treat AD,this study analyzes and organizes literature from the past 30 years.From the perspective of microorganisms,it examines the correlation between oral-intestinal flora imbalance and the pathogenesis of AD,and categorizes representative Chinese medicines and their components that regulate oral and intestinal flora to intervene in AD.It aims to provide new insights for the in-depth research on the mechanism of action of Chinese medicines in preventing and treating AD,as well as for the development of new anti-AD drugs from Chinese medicines.
万方数据