间充质干细胞外泌体在骨肉瘤治疗中的研究进展
Research Progress of Mesenchymal Stem Cell-Derived Exosomes in Treatment of Osteosarcoma
王福财 1刘卓晟1
作者信息
- 1. 华侨大学医学院,福建泉州 362021
- 折叠
摘要
阐述间充质干细胞外泌体(MSC-Exos)在骨肉瘤(OS)治疗中的研究进展.通过查阅近年的相关文献,综述OS的研究现状、发病机制和潜在治疗靶点,MSC-Exos的生物学特性和功能,以及MSC-Exos在OS的靶向治疗、肿瘤耐药性和作为药物递送载体等方面的研究进展.结果表明:MSC-Exos作为一种新兴的生物治疗剂,在OS治疗领域具有广阔的应用前景.
Abstract
To elucidate the research progress of mesenchymal stem cell-derived exosomes(MSC-Exos)in the treatment of osteosarcoma(OS).By reviewing recent relevant literature,summarizes the current status,path-ogenesis,and potential therapeutic targets of OS,the biological characteristics and functions of MSC-Exos,as well as the research progress of MSC-Exos in the OS targeted therapy,tumor drug resistance and as a drug de-livery carrier.The results show that MSC-Exos,as a novel biological therapeutic agent,has broad application prospects in the field of treatment of OS.
关键词
间充质干细胞/外泌体/骨肉瘤/靶向治疗/肿瘤耐药性Key words
mesenchymal stem cells/exosomes/osteosarcoma/targeted therapy/tumor resistance引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据