Gastric Metastasis from Renal Cell Carcinoma 1 Case:a Clinicopathological Analysis and Review of the Literature
Objective To investigate the clinical features,pathological morphology,immunohistochemical features and differential diagnosis of gastric metastasis from renal cell carcinoma(RCC),reduce misdiagnosis.Methods The clinical and pathological data of a case of solitary gastric metastasis from renal cell carcinoma were analyzed retrospectively.Results The patient was a 71-year-old man who underwent gastroscopy during a healthy physical examination.Pathological examination revealed diffuse nests and sheets of proliferating tumor cells in the mucosa and submucosa,the nuclei were small,the nuclear membrane was regular,the cytoplasm was clear or eosinophilic,and the interstitial blood vessels were abundant.The immunohistochemical expression of CK(pan),PAX-8,CD10 and CAIX were observed.The patient underwent right nephrectomy for clear cell renal cell carcinoma 5 years ago.The pathological diagnosis was metastatic clear cell renal cell carcinoma of the stomach.Conclusion The solitary gastric metastasis of renal cell carcinoma is very rare,and the cell morphology is mild.The average time from diagnosis to discovery of gastric metastasis of renal cell carcinoma is long,and the imaging and endoscopic findings are not special,so it is easy to misdiagnose and miss the diagnosis in pathological diagnosis.