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肾细胞癌胃转移一例临床病理分析并文献复习

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目的 探讨肾细胞癌胃转移的临床特征、病理学形态、免疫组化特点、鉴别诊断,减少误诊。方法 回顾性分析1例肾细胞癌孤立性胃转移患者的临床、病理资料,复习国内外相关文献。结果 患者男性,71岁,健康查体时胃镜检查显示胃底隆起性病变,病理活检示黏膜层及黏膜下层弥漫巢状、片状增生的肿瘤细胞,细胞形态温和,核小、核膜规则,可见小核仁,胞质透明或嗜酸,间质血管丰富,免疫组化表达CK(pan)、PAX-8、CD10及CAIX。追溯病史,患者5年前因透明细胞肾细胞癌行右肾切除,病理诊断为胃转移性透明细胞肾细胞癌。结论 肾细胞癌孤立性胃转移非常罕见,细胞形态温和,肾细胞癌的诊断到发现胃转移的平均时间较长,影像学和内镜表现无特殊,因此病理诊断中极易误诊和漏诊。
Gastric Metastasis from Renal Cell Carcinoma 1 Case:a Clinicopathological Analysis and Review of the Literature
Objective To investigate the clinical features,pathological morphology,immunohistochemical features and differential diagnosis of gastric metastasis from renal cell carcinoma(RCC),reduce misdiagnosis.Methods The clinical and pathological data of a case of solitary gastric metastasis from renal cell carcinoma were analyzed retrospectively.Results The patient was a 71-year-old man who underwent gastroscopy during a healthy physical examination.Pathological examination revealed diffuse nests and sheets of proliferating tumor cells in the mucosa and submucosa,the nuclei were small,the nuclear membrane was regular,the cytoplasm was clear or eosinophilic,and the interstitial blood vessels were abundant.The immunohistochemical expression of CK(pan),PAX-8,CD10 and CAIX were observed.The patient underwent right nephrectomy for clear cell renal cell carcinoma 5 years ago.The pathological diagnosis was metastatic clear cell renal cell carcinoma of the stomach.Conclusion The solitary gastric metastasis of renal cell carcinoma is very rare,and the cell morphology is mild.The average time from diagnosis to discovery of gastric metastasis of renal cell carcinoma is long,and the imaging and endoscopic findings are not special,so it is easy to misdiagnose and miss the diagnosis in pathological diagnosis.

Renal Cell CarcinomaSolitary Gastric MetastasisClinical CharacteristicsImmunohistochemistry

周福安、杜翠霞、纪海勇

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山东省宁津县人民医院病理科(山东德州 253400)

山东省宁津县人民医院泌尿、小儿外科(山东德州 253400)

肾细胞癌 孤立性胃转移 临床特点 免疫组织化学

2025

罕少疾病杂志
深圳市卫生局

罕少疾病杂志

影响因子:0.583
ISSN:1009-3257
年,卷(期):2025.32(1)