Analysis of Pathogenic Bacteria Characteristics and Influencing Factors of Refractory Suppurative Meningitis in Neonates
Objective To explore the characteristics of pathogenic bacteria of refractory suppurative meningitis in newborns and analyze the influencing factors of the onset of refractory suppurative meningitis in newborns.Methods The clinical data of 47 neonates with refractory suppurative meningitis admitted to our hospital from March 2021 to December 2022 were retrospectively analyzed and taken as the observation group.The clinical data of 47 neonates with common suppurative meningitis admitted in the same period were set as control group.The treatment effect,distribution of pathogenic bacteria,clinical symptoms,cerebrospinal fluid related index level and brain MRI examination results of the two groups were compared.Logistic regression analysis was performed on the influencing factors of refractory suppurative meningitis in newborns.Results The total effective rate of the observation group was 72.34％,which was significantly lower than that of the control group(89.36％,P＜0.05).The incidence of convulsion in the observation group was 25.53％higher than that in the control group(8.51％,P＜0.05).The content of cerebrospinal fluid sugar in the observation group was lower than that in the control group(P＜0.05).The cerebrospinal fluid protein content,cerebrospinal fluid leukocyte count and lactate dehydrogenase content in the observation group were higher than those in the control group(P＜0.05).The occurrence of convulsion,cerebrospinal fluid protein content,cerebrospinal fluid white blood cell count and lactate dehydrogenase content are the risk factors of refractory suppurative meningitis in newborns,and the cerebrospinal fluid sugar content is the protective factor of refractory suppurative meningitis in newborns(P＜0.05).Conclusion There are many factors that affect refractory suppurative meningitis in newborns.Clinicians should give corresponding intervention measures to prevent the occurrence of this disease.
Refractory Suppurative MeningitisNewbornCharacteristics of Pathogenic BacteriaInfluencing FactorsCerebrospinal Fluid
万方数据
维普
