Objective To investigate the effects of flupentixol-melitracen combined with lorazepam tablets on sleep quality and negative emotions in patients with insomnia.Methods The clinical data of 32 patients with insomnia who received lorazepam tablets from January 2021 to December 2023 were retrospectively collected as the control group,and the clinical data of 32 patients with insomnia who received flupentixol-melitracen combined with lorazepam tablets were collected as the observation group.Sleep quality,negative emotions,polysomnosis parameters and adverse drug reactions were compared between the two groups.Results After treatment,the Pittsburgh Sleep Quality Index(PSQI)of the observation group was lower than that of the control group(P＜0.05).The actual total sleep time and rapid eye movement sleep phase sleep time(RT)of the observation group were longer than those of the control group.Compared with the control group,the proportion of sleep latency,number of nocturnal awakenings,awakening time,and non rapid eye movement sleep stage 1(S1)was shorter(P＜0.05).The scores of Self Rating Anxiety Scale(SAS)and Self Rating Depression Scale(SDS)in the observation group were lower than those in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse drug reactions between the two groups(P＞0.05).Conclusion The combination of flupentixol-melitracen with lorazepam tablets has an improvement effect on sleep quality and negative emotions in patients with insomnia,and is relatively safe.
Flupentixol-melitracenLorazepam TabletsinsomniaPittsburgh Sleep Quality index
维普
万方数据
