Analysis of the Relationships between Ultrasound Parameters and Lipid Metabolism and Vulnerability in Patients with Carotid Atherosclerosis Plaque
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维普
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目的 探讨超声参数与颈动脉粥样硬化斑块形成患者脂代谢、易损性的关系.方法 选取2022年1月至2023年6月本院收治的112例颈动脉粥样硬化患者为观察组,另选取同期健康体检者112例为对照组,均行超声检查及血脂[甘油三酯(TRIG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、高密度脂蛋白胆固醇/总胆固醇比值(HDL-C/TC)、低密度脂蛋白胆固醇/总胆固醇比值(LDL-C/TC)]检测.另根据斑块性质将患者分为易损组与稳定组,比较此两组超声参数与血脂指标.采用Pearson相关系数分析超声参数与颈动脉粥样硬化斑块形成患者血脂指标、易损性的关系.结果 观察组颈动脉内-中膜厚度(IMT)、平均血流速度(MFV)、阻力指数(RI)、搏动指数(PI)及TRIG、TC、LDL-C水平均高于对照组(P＜0.05),颈动脉血管内径(VD)、HDL-C、HDL-C/TC均低于对照组(P＜0.05),组间LDL-C/TC比较无差异(P＞0.05);易损组IMT及TRIG、TC、LDL-C水平均高于稳定组(P＜0.05),HDL-C/TC低于稳定组(P＜0.05);IMT与斑块易损性呈正相关(P＜0.05);IMT、MFV、PI、RI与TRIG、TC、LDL-C均呈正相关(P＜0.05),与HDL-C、HDL-C/TC均呈负相关(P＜0.05);VD与TRIG、TC、LDL-C均呈负相关(P＜0.05),与HDL-C、HDL-C/TC均呈正相关(P＜0.05).结论 I MT与颈动脉粥样硬化斑块形成患者脂代谢、斑块易损性具有相关性,且MFV、PI、RI、VD亦与脂代谢存在一定的关系.
Objective To explore the relationships between ultrasound parameters and lipid metabolism and vulnerability in patients with carotid atherosclerosis plaque.Methods 112 patients with carotid atherosclerosis admitted to our hospital from January 2022 to June 2023 were selected as the observation group,and 112 people with physical examination at the same time were selected as the control group,and all of them were examined by ultrasound and blood lipid[triglycerides(TRIG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),high-density lipoprotein cholesterol/total cholesterol(HDL-C/TC)ratio,low-density lipoprotein cholesterol/total cholesterol(LDL-C/TC)ratio].According to the nature of the plaque,patients were divided into vulnerable group and stable group,and the ultrasound parameters and blood lipid indicators between these two groups were compared.The relationships between ultrasound parameters and blood lipid indicators and vulnerability in patients with carotid atherosclerosis plaque were analyzed by Pearson correlation coefficient.Results The carotid intima-media thickness(IMT),mean flow velocity(MFV),resistance index(RI),pulsatility index(PI)and the levels of TRIG,TC and LDL-C in the observation group were higher than control group(P＜0.05),while carotid artery diameter(VD),HDL-C and HDL-C/TC were lower than control group(P＜0.05),but there was no difference in LDL-C/TC between groups(P＞0.05).The IMT and TRIG,TC,LDL-C levels in the vulnerable group were higher than stable group(P＜0.05),while HDL-C/TC was lower than stable group(P＜0.05).The IMT was positively correlated with plaque vulnerability(P＜0.05).The IMT,MFV,PI and RI were positively correlated with TRIG,TC and LDL-C(P＜0.05),while they were negatively correlated with HDL-C and HDL-C/TC(P＜0.05).The VD was negatively correlated with TRIG,TC and LDL-C(P＜0.05),but it was positively correlated with HDL-C and HDL-C/TC(P＜0.05).Conclusion IMT is related to lipid metabolism and plaque vulnerability in patients with carotid atherosclerotic plaque,and MFV,PI,RI and VD also have a certain relationship with lipid metabolism.
维普
万方数据
