首页|电子支气管镜肺泡灌洗术治疗儿童大叶性肺炎的疗效观察及炎症因子表达的研究

电子支气管镜肺泡灌洗术治疗儿童大叶性肺炎的疗效观察及炎症因子表达的研究

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目的 探究电子支气管镜肺泡灌洗术治疗儿童大叶性肺炎的疗效及炎症因子的表达水平。方法 选取本院2021年1月至2022年12月收住院治疗的100例大叶性肺炎儿童,随机分成两组,对照组48例,给予抗感染、雾化及对症支持治疗;实验组52例,在对照组的基础上给予电子支气管镜肺泡灌洗治疗,实验组根据不同病程又分为早期灌洗组28例,晚期灌洗组24例。观察不同组之间患儿的发热消退时间、咳嗽、咳痰消退时间、肺部啰音消退时间、肺部影像学吸收时间、住院天数以及早期灌洗组与晚期灌洗组患儿血液中炎症因子白介素-6(Interleukins-6,IL-6)的表达水平。结果 (1)早期灌洗组患儿的热退时间、咳嗽、咳痰消退时间、肺部啰音消退时间、肺部炎症吸收时间、住院天数均少于对照组与晚期灌洗组,差异有统计学意义(P<0。05)。(2)晚期灌洗组与对照组相比,仅在肺部啰音消失时间及肺部炎症吸收时间差异有统计学意义(P<0。05)。(3)晚期灌洗组患儿血液中白介素-6表达水平较早期灌洗组高,随着大叶性肺炎病程的延长,肺部炎症分泌物积聚,会导致肺部炎症面积扩散,进而引起炎症因子水平表达增高。结论 大叶性肺炎患儿早期进行电子支气管镜肺泡灌洗有利于病情的恢复,值得在临床推广应用。
Observation of Curative Effect and Expression of Inflammatory Factors by Electronic Bronchoscopy in the Treatment of Children with Lobar Pneumonia
Objective To explore the efficacy of electronic bronchoscopy with bronchoalveolar lavage in the treatment of children with lobar pneumonia and observe the expression levels of inflammatory factors.Methods A total of 100 children with lobar pneumonia who were hospitalized in our hospital from January 2021 to December 2022 were selected and randomly divided into two groups,and 48 cases in the control group were given intravenous anti-infection,nebulization and symptomatic supportive treatment;52 cases in the experimental group were given electronic bronchoscopy bronchoalveolar lavage treatment on the basis of the control group.The experimental group was divided into an early lavage group with 28 cases and a late lavage group with 24 cases according to different disease courses.The fever subsidence time,the disappearance time of cough and sputum,the disappearance time of pulmonary rales,the absorption time of lung imaging,the length of hospitalization,and the inflammation in the blood of the children in the early lavage group and the late lavage group were observed between different groups.Expression levels of the factor lnterleukins-6(IL-6).Results 1.The fever subsidence time,the disappearance time of cough and expectoration,the disappearance time of lung rales,the absorption time of pulmonary inflammation,and the length of hospital stay of the children in the early lavage group were all shorter than those in the control group and the late lavage group,and the differences were as follows:Statistical significance(P<0.05).2.Compared with the control group,the late lavage group only had significant differences in the disappearance time of pulmonary rales and the absorption time of pulmonary inflammation(P<0.05).3.The expression level of interleukin-6 in the blood of the children in the late lavage group was higher than that in the early lavage group.With the prolongation of the course of lobar pneumonia,the accumulation of inflammatory secretions in the lungs would lead to the spread of the inflammatory area in the lungs,which in turn caused inflammation The expression of the factor was increased.Conclusion Therefore,early electronic bronchoscopy with bronchoalveolar lavage in children with lobar pneumonia is beneficial to the recovery of the disease and is worthy of clinical application.

Electronic BronchoscopyAlveolar lavageLobar pneumoniaInterleukin-6

雷佳佳、刘伟伟、张倩倩、赵黎英

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巩义市人民医院儿科(河南巩义 451200)

电子支气管镜 肺泡灌洗术 大叶性肺炎 白介素-6

2025

罕少疾病杂志
深圳市卫生局

罕少疾病杂志

影响因子:0.583
ISSN:1009-3257
年,卷(期):2025.32(1)