Effect of Coenzyme Q10 Tablets Assisting Metoprolol in the Treatment of Hypertension Combined with Ventricular Arrhythmias
Objective To explore the application effect of coenzyme Q10 tablets as an adjunct to metoprolol in patients with hypertension complicated with ventricular arrhythmias.Methods A retrospective study was conducted to collect medical records of 52 hypertensive patients with ventricular arrhythmias who received metoprolol treatment in the hospital from January 2021 to December 2023,and they were included in the control group.Medical records of 52 patients with hypertension complicated with ventricular arrhythmias who received coenzyme Q10 tablets as adjuvant therapy in the hospital were collected during the same period,and included in the observation group.All clinical data of patients were well preserved.The patient's medical records were reviewed,and the treatment effects,blood pressure indexes,heart rate indexes,electrocardiogram indexes,myocardial injury indexes before and after treatment,and the occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of the observation group was 96.15％,which was higher than the total effective rate of the control group by 84.62％,with a statistical significant difference(P＜0.05).After treatment,both diastolic and systolic blood pressure decreased in both groups,and the observation group was lower than the control group,with a statistical significant difference(P＜0.05).After treatment,the heart rate,frequency of sinus arrhythmias,QT interval dispersion(QTd),and QT corrected dispersion(QTcd)of both groups decreased,and the observation group was lower than the control group,with a statistical significant difference(P＜0.05).After treatment,the levels of cardiac troponin Ⅰ(cTnⅠ),creatine kinase isoenzyme(CK-MB),and myoglobin(Myo)decreased in both groups,and the observation group was lower than the control group,with a statistical significant difference(P＜0.05).There is no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of using coenzyme Q10 tablets as an adjunct to metoprolol in the treatment of hypertensive patients with ventricular arrhythmia is significant.It can effectively reduce blood pressure,improve arrhythmia symptoms,promote myocardial cell repair,and has good safety.
万方数据
维普
