The Diagnostic Effect of CA19-9,CEA,AFP Detection Combined with 128-layer MSCT in the Diagnosis of Early Esophageal Cancer
Objective To analyze the diagnostic effect of Carbohydrate antigen 19-9(CA19-9),Carcinoembryonic antigen(CEA),Alpha fetoprotein(AFP)detection combined with 128-slice multi-slice spiral CT(MSCT)in the diagnosis of early esophageal cancer.Methods The clinical data of 92 patients with esophageal cancer admitted to our hospital from June 2021 to October 2023 were collected(esophageal cancer group).63 healthy people who underwent physical examination during the same period in our hospital were selected as the control group.Observed the CT signs of esophageal cancer such as size,shape and density,compared the levels of CA19-9,CEA,and AFP in different populations;drew a receiver operating characteristic curve(ROC),and analyzed the diagnostic value of the combination of MSCT and CA19-9,CEA,AFP for early esophageal cancer.Results The levels of CA19-9,CEA and AFP in the esophageal cancer group were significantly higher than those in the control group(P＜0.05).Serum levels of CA19-9,CEA and AFP1 in patients with stage Ⅰ-Ⅱ esophageal cancer were significantly lower than those with stage Ⅲ-Ⅳ(P＜0.05).The ROC curve showed that the area under the curve(AUC),sensitivity,and specificity of the combined detection of MSCT,CA19-9,CEA,and AFP were 0.915,0.965,and 0.863,respectively,which were all higher than those detected separately.Conclusion CA19-9,CEA,and AFP are all highly expressed in esophageal cancer,which may be related to the occurrence and development of esophageal cancer;and the combination of the above factors and MSCT can improve the diagnostic value of early esophageal cancer.
万方数据
维普
