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早期乳腺浸润性小叶癌诊断中超声引导下粗针穿刺病理检查的应用研究

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目的 分析早期乳腺浸润性小叶癌诊断中超声引导下粗针穿刺病理检查的应用价值。方法 选取180例早期乳腺癌患者,均为我院2018年4月至2022年12月所收治,按照术后组织病理学检查结果将全部患者分为早期乳腺浸润性小叶癌(小叶癌组,n=70例)与其他早期乳腺癌(对照组,n=110例)。术前全部患者均接受超声引导下粗针穿刺组织学检查和细针穿刺组织学检查,同时和术后组织病理学检查结果比较,分析超声引导下粗针穿刺组织学检查的价值。结果 超声引导下细针穿刺组织病理学检查结果显示,50例患者为早期乳腺浸润性小叶癌,130例患者为其他早期乳腺癌;超声引导下粗针穿刺组织病理学检查结果显示,61例患者为早期乳腺浸润性小叶癌,119例患者为其他早期乳腺癌。超声引导下粗针穿刺检查的诊断敏感度显著高于超声引导下细针穿刺检查(P<0。05),而在诊断准确度、特异度方面,两组比较差异无统计学意义(P>0。05)。超声引导粗针穿刺组织病理学检查结果显示,小叶癌组的HER-2阳性表达率显著高于对照组(P<0。05),而在PR阳性表达率、ER阳性表达率方面,两组比较差异无统计学意义(P>0。05)。结论 在诊断早期乳腺浸润性小叶癌时,应用超声引导下粗针穿刺病理检查具有较高的诊断敏感性,患者具有较高的HER-2阳性表达率。
Application of Ultrasound-guided Coarse Needle Biopsy in the Diagnosis of Early Invasive Lobular Carcinoma of the Breast
Objective To analyze the application value of ultrasound-guided coarse needle biopsy in the diagnosis of early invasive lobular carcinoma of the breast.Methods 180 patients with early breast cancer were selected from our hospital from April 2018 to December 2022.According to the results of postoperative histopathology,all patients were divided into early invasive lobular breast cancer(lobular cancer group,n=70 cases)and other early breast cancer(control group,n=110 cases).All patients underwent ultrasound-guided histology and fine-needle aspiration before operation.At the same time,the value of ultrasound-guided histology and fine-needle aspiration was analyzed by comparing with the results of postoperative histopathology.Results The results of ultrasound-guided fine needle aspiration histopathology showed that 50 patients were early invasive lobular breast cancer,and 130 patients were other early breast cancer.The results of ultrasound-guided thick needle biopsy showed that 61 patients were early invasive lobular breast cancer,and 119 patients were other early breast cancer.The diagnostic sensitivity of ultrasound-guided coarse needle aspiration was significantly higher than that of ultrasound-guided fine needle aspiration(P<0.05).The results of ultrasound-guided biopsy showed that the positive expression rate of HER-2 in lobular carcinoma group was significantly higher than that in control group(P<0.05).Conclusion In the diagnosis of early invasive lobular carcinoma of the breast,ultrasound-guided coarse needle biopsy has a high diagnostic sensitivity,and the patients have a high positive expression rate of HER-2.

Early StageInfiltrating Lobular Carcinoma of BreastUltrasound GuidanceCoarse Needle PuncturePathological Examination

杨平、赵帅华

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安阳市第三人民医院病理科(河南安阳 455000)

濮阳市安阳地区医院病理科(河南安阳 455000)

早期 乳腺浸润性小叶癌 超声引导 粗针穿刺 病理检查

2025

罕少疾病杂志
深圳市卫生局

罕少疾病杂志

影响因子:0.583
ISSN:1009-3257
年,卷(期):2025.32(1)