The Expression and Clinical Significance of FOLR1 and PSMA in Normal Endometrium,Atypical Hyperplasia,and Cancer Tissues
Objective To investigate the expression of folic acid receptor 1(FOLR1)and prostate-specific membrane antigen(PSMA)in different endometrial tissues.Methods From January 2021 to August 2023,98 paraffin-embedded specimens of endometrial cancer,30 specimens of atypical endometrial and 30 specimens of normal endometrial were collected from the Department of Pathology of the Fifth Affiliated Hospital of Zhengzhou University.FOLR1 and PSMA were detected by immunohistochemical staining.The positive expression of FOLR1 and PSMA in normal endometrial,atypical hyperplasia and cancer tissues was compared,and the correlation between the positive expression of FOLR1 and PSMA and clinicopathological features of endometrial cancer patients was analyzed.Results The positive expression rates of FOLR1 and PSMA in endometrial carcinoma were higher than those in normal endometrial with atypical hyperplasia(P＜0.05).The positive expression rates of FOLR1 and PSMA in endometrium with atypical hyperplasia were higher than those in normal endometrium,but there was no statistical difference(P＞0.05).There was no significant difference in FOLR1 and PSMA expression rate among different age,histological type and differentiation degree of endometrial carcinoma(P＞0.05).The positive expression rates of FOLR1 and PSMA in endometrial carcinoma with vascular invasion and lymph node metastasis were higher than those without vascular invasion and lymph node metastasis,and the positive expression rates of FOLR1 and PSMA in endometrial carcinoma with Ⅲ+Ⅳ stage were higher in endometrial carcinoma with Ⅰ+Ⅱ stage,the difference was statistically significant(P＜0.05).FIGO stage,vascular invasion and lymph node metastasis were positively correlated with FOLR1 and PSMA expression in endometrial carcinoma patients(P＜0.05).Conclusion PSMA and FOLR1 can promote the progression of endometrial carcinoma,and their positive expression rates are closely related to FIGO stage,vascular invasion and lymph node metastasis.
Endometrial CancerFolate Receptor 1Clinical Pathological CharacteristicsProstate Specific Membrane Antigen
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维普
