Objective To investigate the relationship between the expression levels of runt-related transcription factor 3(runtrelated transcription factor 3,Runx3)and hypoxia-inducible factor-1α(hypoxia-Inducible Factor 1-Alpha,HIF-1α)proteins in mucosal tissues and different types of gastric polyps,as well as their association with Helicobacter pylori(H.pylori,Hp)infection.Methods A total of 154 patients with gastric polyps treated at our hospital from January 2018 to January 2022 were included as Group A.Additionally,120 patients with chronic atrophic gastritis were included as Group B,and 120 patients with gastric cancer as Group C.Diagnoses were confirmed via gastric mucosal biopsy.The expression levels of Runx3 and HIF-1α proteins and the Hp positivity rates in all groups were assessed.Correlations between Runx3,HIF-1α proteins,and Hp infection in patients with gastric polyps were analyzed.Results The positive expression rates of Runx3 and HIF-1α in Groups A,B,and C were 62.99％vs.47.40％,75.33％vs.33.33％,and 31.67％vs.85.83％,respectively(P＜0.001).Significant differences were found in Runx3 and HIF-1α positivity rates between the hyperplastic polyp subgroup and Group C(P＜0.001),while no significant differences were observed between the hyperplastic polyp subgroup and Group B(P＞0.05).Conversely,no significant differences were found between the adenomatous polyp subgroup and Group C(P＞0.05),but significant differences existed between the adenomatous polyp subgroup and Group B(P＜0.05).Hp positivity rates in Groups A,B,and C were 45.45％,40.83％,and 84.17％,respectively(P＜0.001).Significant differences in Hp positivity were observed between the hyperplastic polyp subgroup and Group C(P＜0.001)but not between the hyperplastic polyp subgroup and Group B(P＞0.05).Similarly,no differences were observed between the adenomatous polyp subgroup and Group C(P＞0.05),while differences existed between the adenomatous polyp subgroup and Group B(P＜0.05).Among Hp-positive patients,the positive expression rates of Runx3 and HIF-1α were 24.29％and 52.86％,respectively,while in Hp-negative patients,the rates were 95.24％and 42.86％,respectively.Correlation analysis revealed a significant negative correlation between Runx3 expression and Hp infection in gastric polyp patients(r=-0.732,P＜0.001),whereas no significant correlation was found between HIF-1α expression and Hp infection(r=0.100,P=0.213).Conclusion Runx3、HIF-1α Protein is highly expressed in the mucosal tissue of patients with gastric polyps,and Hp infection may be involved in the occurrence and development of gastric polyps.Runx3 is negatively correlated with it.
维普
万方数据
