Objective To investigate the diagnostic value of enteric fatty acid-binding protein(I-FABP)and C-reactive protein(CRP)combined with superior mesenteric artery(SMA)ultrasonography in neonates with necrotizing enterocolitis(NEC).Methods From May 2020 to May 2022,80 patients with suspected NEC(Bell stage Ⅰ),72 patients with confirmed NEC(Bell stage Ⅱ)and 40 neonates without gastrointestinal disease were selected(control group).The peak systolic flow rate(PSV),end-diastolic flow rate(EDV)and resistance index(RI)of SMA were detected by color Doppler ultrasound,and the serum I-FABP and CRP levels were also detected.Results There were significant differences in PSV,EDV and RI among the three groups at the first SMA examination(P＜0.05).Compared with the control group,PSV in the suspected group was significantly decreased(P＜0.05),RI was significantly increased(P＜0.05),but EDV was not significantly different(P＞0.05).Compared with confirmed group,RI in suspected group was significantly decreased(P＜0.05),while PSV and EDV were not significantly different(P＞0.05).The levels of serum I-FABP and CRP in the three groups were statistically significant(P＜0.05).Compared with the control group,the levels of serum l-FABP and CRP in the suspected group were significantly increased(P＜0.05).Compared with the confirmed group,the level of l-FABP in the suspected group was significantly decreased(P＜0.05),but there was no significant difference in CRP(P＞0.05).ROC curve analysis showed that the sensitivity and specificity of SMA ultrasound+I-FABP+CRP in the diagnosis of early NEC were 87.1％and 85.9％,respectively,and the AUC was 0.834(95％CI:0.712-0.926),which were higher than that of single diagnosis.Conclusion Ultrasound examination of l-FABP,CRP and SMA is valuable in the diagnosis of NEC,and the combination of the three has high sensitivity and specificity for NEC.
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