Objective To analyze the incidence and related factors of incisional infection(SSI)in children undergoing acute appendicitis(AA)surgery during hospitalization.Methods The clinical data of 68 children with AA operation from July 2022 to July 2023 were retrospectively analyzed,and the patients with SSI were divided into the occurrence group according to whether SSI occurred during hospitalization,and the patients without SSI were divided into the non-occurrence group.The disease-related characteristics and general data of the children in the two groups were collected.The factors related to SSI during hospitalization of children with AA surgery were analyzed,and the differences were analyzed by Logistic regression.Results Among 68 children with AA operation,19 cases developed SSI(27.94%),while 49 cases did not,accounting for 72.06%.There were no significant differences in age,physical sign index(BMI),gender,underlying diseases,incision type,incision method,incision protection and preoperative CRP levels between the two groups(P>0.05).There were significant differences between the occurrence group and the non-occurrence group(P<0.05)in the use of prophylactics,indindent abdominal drainage tube,operation time and appendix perforation.Logistic regression equation was used to calculate the above difference items,and it was found that the use of prophylactic antibiotics,indentation of abdominal drainage tube,operation time,and appendix perforation were risk factors for SSI in children with AA.Conclusion There are many factors for the occurrence of SSI in children with AA surgery during hospitalization,such as the use of prophylactic antibiotics,the indentation of abdominal drainage tube,the operation time,and appendix perforation,which should be paid high attention in clinic to minimize the risk of SSI occurrence.