Effect of Omega-3 Polyunsaturated Fatty Acids on Serum Inflammatory Factor Levels and Prognosis in Patients with STBI Undergoing Enteral Nutrition Support Therapy
Objective To observe the effect of omega-3 polyunsaturated fatty acids(omega-3 PUFAs)on serum inflammatory factor levels and prognosis in patients with severe traumatic brain injury(STBI)undergoing enteral nutrition(EN)support therapy.Methods A total of 80 patients with STBI who were admitted to the hospital from January 2021 to December 2023 were randomly assigned to the observation group and the control group,with 40 patients in each group.On the basis of conventional EN support,the observation group and the control group were treated with the same calorie of omega-3 fish oil fat emulsion and fat emulsion injection,respectively.Both groups were treated for 14 days.The nutritional indicators,immune indicators,serum inflammatory factor levels and Glasgow Outcome Scale(GOS)scores were compared between the groups.Results After treatment,there were significant decreases in inflammatory factor levels in the observation group(P＜0.05).After treatment,nutritional indicators decreased,but the indicators in observation group were higher than those in control group(P＜0.05).After treatment,the levels of T cell subsets in observation group were significantly lower than those in control group(P＜0.05).After treatment,GOS scores increased and observation group had significantly higher scores than control group(P＜0.05).Conclusion Applying omega-3 PUFAs in EN support for patients with STBI can help to improve patients'anti-inflammatory and immune ability,improve their gastrointestinal function and prognosis.
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