Analysis of the Changes of Serum Neurotransmitters in Patients with Bipolar Disorder Depression and Their Relationship with Stigma and Sleep Quality
Objective To observe the changes of serum neurotransmitter levels in patients with bipolar disorder(BD)depressive episode,and explore their relationship with stigma and sleep quality.Methods A total of 243 patients with BD depression admitted to our hospital from January 2020 to December 2022 were selected as the observation group,and 243 healthy people in the same period were selected as the control group.The levels of serum neurotransmitters[γ-aminobutyric acid(GABA),neuropeptide Y(NPY),5-hydroxytryptamine]in the observation group and the control group were detected by enzyme-linked immunosorbent assay.The stigma scale and Pittsburgh Sleep Quality Index(PSQI)scale were used to evaluate the stigma and sleep quality of the patients in the observation group.Pearson correlation analysis was used to explore the relationship between serum neurotransmitter changes and stigma and sleep quality in patients with BD depression.Results The levels of serum GABA,NPY and 5-HT in the observation group were lower than those in the control group(P＜0.05).The total average score of derogation-discrimination perception of 243 BD patients with depressive episodes was(34.20±3.23)points,the total average score of stigma induction was(78.14±12.36)points,the total average score of stigma emotional experience was(18.11±2.61)points,and the total average score of PSQI was(13.48±3.68)points.The levels of serum GABA,NPY and 5-HT were negatively correlated with the scores of derogatory-discrimination perception,stigma perception,stigma emotional experience and sleep quality(P＜0.05).Conclusion The levels of serum neurotransmitters GABA,NPY and 5-HT are decreased in patients with BD depression,and they are closely related to the stigma and sleep quality of patients.
万方数据
维普
