Exploring the Clinical Prognosis of Hemodialysis Through Inflammatory Factor Curves
Objective Exploring the clinical prediction of hemodialysis through the curves of inflammatory factors such as interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(Pct).Methods A retrospective study was conducted to select the of 120 MHD patients who completed 1-year follow-up in the hospital from January 2023 to December 2023 as the research object.According to the prognosis of patients,patients who died within 1 year of follow-up were included in the poor prognosis group(n=31),and patients who survived were included in the good prognosis group(n=89).The baseline data and the levels of inflammatory factors(IL-6,CRP,Pct)were compared between the two groups.Cox regression analysis was used to test the influencing factors of poor prognosis in MHD patients.The receiver operating characteristic(ROC)curve was used to predict the predictive value of serum IL-6,CRP and Pct levels in the poor prognosis of MHD patients.R4.1.3 statistical software was used to draw the decision curve of serum IL-6,CRP and Pct levels to predict the poor prognosis of MHD patients.Results The dialysis age of the poor prognosis group was longer than that of the good prognosis group,the proportion of malnutrition was higher than that of the good prognosis group,and the levels of serum IL-6,CRP and Pct were higher than those of the good prognosis group(P＜0.05).Cox regression analysis showed that IL-6,CRP,Pct,dialysis age and malnutrition were independent risk factors for poor prognosis in MHD patients(HR＞1,P＜0.05);The results of ROC curve showed that the AUC of serum IL-6,CRP,Pct levels and combined examination in predicting poor prognosis of MHD patients were all＞0.70,which had certain predictive value,and the combined predictive value of the three was the highest.The decision curve was drawn.The results showed that in the range of threshold 0.000～0.446、0.658～1.000,the combined prediction of serum IL-6,CRP and Pct levels in MHD patients with poor prognosis was better than the single net rate of return.Conclusion Serum IL-6,CRP and Pct levels are independent risk factors for poor prognosis in MHD patients.Combined detection has the highest predictive efficacy and can be used to predict the prognosis of MHD patients.
万方数据
维普
