Advances in mechanical response and transduction mechanisms of the cardiovascular system in the microgravity environment
Gravity is one of the most widespread mechanomechanical signals affecting surface organisms and plays a key role in maintaining normal cardiovascular structure and function.The absence of gravity in the space environment leads to changes in the physiological-mechanical environment of the cardiovascular system,potentially causing adaptive changes or remodelling of the cardiovascular system in terms of structure and function.However,how the cardiovascular system senses,transduces,and responds to altered mechanical stress in the microgravity environment remains poorly understood by humans.In this paper,we reviewed the research findings on mechanoreceptors and mechano-transduction of cardiovascular system in recent years,analyzed the mechanisms of mechanical perception and response to microgravity in cardiovascular system,and predicted the novel mechanoreceptors,key signaling pathways,and potential targets for intervention in space microgravity.This article aims to provide new ideas for combating adaptive changes in the cardiovascular system due to space microgravity.
NETL
NSTL
万方数据
