微重力环境下心血管系统的机械应答及转导机制研究进展
Advances in mechanical response and transduction mechanisms of the cardiovascular system in the microgravity environment
凡浩 1李源 1雷伟 1韩兴龙 1胡士军1
作者信息
- 1. 苏州大学心血管病研究所,苏州 215007
- 折叠
摘要
重力是对地表生物影响最广泛的机械力学信号之一,在维持心血管正常结构和功能方面发挥关键作用.在太空环境中,重力缺失会导致心血管系统的生理机械环境发生变化,可能引起心血管系统结构和功能方面的适应性改变或重塑.然而,人类对微重力环境下心血管系统如何感知、转导和响应机械应力改变仍知之甚少.本文综述了近年来心血管系统在微重力环境下的机械应力感受器和信号转导研究成果,对心血管系统感知和响应微重力的分子机制,以及新型力学感受器、关键信号通路和潜在干预靶点展开预测和讨论,旨在为防治空间微重力引起的心血管系统适应性改变提供新思路.
Abstract
Gravity is one of the most widespread mechanomechanical signals affecting surface organisms and plays a key role in maintaining normal cardiovascular structure and function.The absence of gravity in the space environment leads to changes in the physiological-mechanical environment of the cardiovascular system,potentially causing adaptive changes or remodelling of the cardiovascular system in terms of structure and function.However,how the cardiovascular system senses,transduces,and responds to altered mechanical stress in the microgravity environment remains poorly understood by humans.In this paper,we reviewed the research findings on mechanoreceptors and mechano-transduction of cardiovascular system in recent years,analyzed the mechanisms of mechanical perception and response to microgravity in cardiovascular system,and predicted the novel mechanoreceptors,key signaling pathways,and potential targets for intervention in space microgravity.This article aims to provide new ideas for combating adaptive changes in the cardiovascular system due to space microgravity.
关键词
微重力/心血管系统/适应性变化/机械感受器/机械转导Key words
microgravity/cardiovascular/adaptive changes/mechanoreceptor/mechano-transduction引用本文复制引用
基金项目
空间站工程航天医学实验项目(HYZHXM01018)
出版年
2024
NETL
NSTL
万方数据