线粒体——空间微重力的细胞内感受器
Mitochondria-The intracellular receptors for spatial microgravity
陈乐融 1王鹏潇 1王珍 1龙建纲1
作者信息
- 1. 西安交通大学生命科学与技术学院,生物医学信息工程教育部重点实验室,线粒体生物医学研究所,西安 710049
- 折叠
摘要
航天飞行过程中的失重效应可引发航天员的机体损伤,这种损伤在航天员返回地球后亦需要较长的恢复时间,甚至发生不可逆损伤.线粒体是细胞内的重要细胞器,参与调节一系列重要的生理和生化过程.线粒体介导的代谢调节能够感应微重力应激,是微重力引发的细胞内早期反应,可推动细胞内代谢的适应以及应激所致损伤的发生.本文综述了微重力和模拟微重力效应对细胞线粒体的影响和相关机制的研究进展,为开发靶向线粒体的防护策略提供理论依据.
Abstract
The weightlessness effect during space flight can cause damage to the astronaut's body,and this damage requires a longer recovery time even after the astronaut returns to Earth,and even irreversible damage may occur.Mitochondria are important organelles within cells,participating in regulating a range of important physiological and biochemical processes.Mitochondrial mediated metabolic regulation can sense microgravity stress,which is an early intracellular response caused by microgravity,promoting the adaptation of intracellular metabolism and stress-induced damage.This article reviews the research progress on the effects and related mechanisms of microgravity and simulated microgravity on cell mitochondria,providing a theoretical basis for the development of protection strategies targeting mitochondria.
关键词
微重力/模拟微重力/线粒体/代谢调节Key words
microgravity/simulated microgravity/mitochondria/metabolic regulation引用本文复制引用
基金项目
载人航天工程航天医学实验领域项目(HYZHXM01023)
出版年
2024
NETL
NSTL
万方数据