Preliminary Study on the Effect of Poria Cocos on Nephrogenic Oedema in Rats
This paper aims to study the effect of Poria cocos on nephrogenic edema in rats,and to explore the possible mechanism of its treatment.150 SD rats were randomly divided into control group(12)and model group(138),and the model was established using doxorubicin.Rats with renal oedema were ran-domly divided into non-administered model group,with low and high doses of Poria cocos powder(raw,cooked,and cultured),low,medium and high alcohol extract,and 8 in each group,half of each male and female,for 21d continuously.Weight changes were recorded on day 0,7,14,21,and blood was harvested on day 21,and serum IL-2,IL-6,ANP,and BNP levels were measured by the Elisa assay.Results show that Poria cocos powder(raw,cooked,and subcultured)had a certain effect on the reduction of oedema degree(weight)and urinary protein,among which cooked Poria cocos powder has the best effect.Poria cocos alcohol extract had the most significant effect on reducing serum ANP and IL-6 in rats with nephro-genic oedema,and all five Poria cocos samples could reduce the levels of serum BNP and IL-2 in rats with nephrogenic oedema.Poria cocos can relieve nephrogenic edema in rats and reduce the levels of serum ANP,BNP,and IL-2 and IL-6.Among them,high dose of cooked Poria cocos had the best effect on relie-ving urinary protein in rats with nephrogenic edema,and Poria alcohol extract had the most obvious effect on reducing serum ANP and IL-6 in rats with nephrogenic edema.indicating that it has a positive effect in the treatment of nephrogenic edema.
万方数据
维普
