A drug quercetin-3-O-acetic acid-(4-(3H-l,2-dithiacyclopentene-3-thione))-phenyl ester with the function of treating diabetes and promoting wound healing was synthesized by using rutin as the starting material and 5-(4-hydroxyphenyl)-3H-l,2-dithiacyclopentene-3-thione as the H2 S donor.The whole process route included a total of five reaction steps including substitution,hydrolysis,williamson etherifi-cation,hydrolysis,and esterification,with a total yield of 6.4％.The products of each step were character-ized by MS and 1H NMR analysis.The synthetic route has the advantages of cheap and easy availability of raw materials,mild reaction conditions and simple operation.
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