Synthesis and Activity Research of Quercetin-3-O-acetic acid-(4-thioamino)-phenyl Ester
A novel compound quercetin-3-O-acetic acid-(4-thioamino)-phenyl ester,which is antidiabetic and promotes wound healing,was synthesized using rutin as raw material and 4-hydroxythiobenzamide as H2S donor.The process route included substitution,hydrolysis,williamson etherification,hydrolysis,re-duction and esterification in six steps with an overall yield of 4.6％.The products of each step were charac-terized by MS and 1H NMR analysis.The compounds were verified by HUVECs cell proliferation assay,scratch assay and insulin resistance model assay to have not only hypoglycemic effect,but also the efficacy of promoting wound healing in diabetic patients.
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