In Vitro Dissolution Determination of Ezetimibe Atorvastatin Calcium Tablets
To investigate the in-vitro-dissolution of ezetimibe atorvastatin calcium tablets by high perform-ance liquid chromatography,and compare similarity factor f2 between self-produced tablets and commer-cially available tablets,the dissolution curves of the self-produced and commercially available tablets were determined by high performance liquid chromatography in various media,and the similarity factor f2 was used to assess the similarity of the dissolution of the two tablets.The linear relationship between ezemibe concentration and peak area was good in the range of 1.20～17.97 pg·ml-1(r=1.0000),and the linear re-lationship between atorvastatin calcium concentration and peak area was good in the range of 4.47～66.98pg·ml-1(r=1.0000).The mean recoveries of ezetimibe and atorvastatin calcium were 99.65％and 99.63％.The f 2 factors of two products in each dissolution medium met the criteria.The method for the de-termination of ezetimibe and atorvastatin calcium solubility created by high performance liquid chromatog-raphy is stable and feasible.
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