Retrospective analysis of 446 cases of conization after colposcopy biopsy diagnosed as low-grade cervical epithelial lesions
Objective:To investigate the concordance between pathological findings of colposcopy biopsies confirmed as low-grade cervical epithelial lesion(LSIL)and pathological findings after diagnostic con-ization and factors associated with postoperative pathological escalation.Methods:This study was performed on 446 patients with LSIL due to colposcopy biopsy histopathology and underwent coniza-tion between January 2010 and June 2022.Results:Pathological findings after diagnostic conization in 446 patients with the cervical intraepithelial lesion(CIN)Ⅰ suggested 221 cases of chronic cervicitis,129 cases of CIN Ⅰ,92 cases of CIN Ⅱ/Ⅲ,2 cases of adenocarcinoma in situ(AIS),and 2 cases of squamous carcinoma.Age,chief complaint and high risk-humanpapilloma virus(HR-HPV)test re-sults were not statistically correlated with postoperative pathological escalation,while the thinprep cy-tology test was strongly correlated with postoperative pathological escalation.Conclusion:Colposco-py biopsy pathology can satisfy the diagnosis of nearly 80％LSIL,but there is a risk of missing le-sions of HSIL and above.Comprehensive consideration of screening results,individualized manage-ment,and appropriately broadening indications for diagnostic conization procedures are needed to re-duce postoperative pathologic escalation.In particular,timely cone biopsy is recommended for ASC-H/HSIL patients to improve the diagnosis of cervical cancer as well as precancerous cervical lesions.
NETL
NSTL
万方数据
维普
