Objective:To investigate the timing of continuous renal replacement therapy(CRRT)for pa-tients with acute kidney injury(AKI)in a non-intensive care unit(non-ICU).Methods:The clinical da-ta of 303 AKI patients who underwent CRRT in the blood purification center of Zhongnan Hospital of Wuhan University from 2013 to 2017 were retrospectively analyzed.According to whether the 24-hour urine volume was less than 0.5 mL/(kg·h)before CRRT,they were divided into the oliguria group and non-oliguria group.The changes before and after CRRT were recorded.AKI patients were grouped according to renal function recovery and death within 30 days after treatment.The differences in various indicators were analyzed between the groups.Logistic regression was used to analyze the in-dependent risk factors for poor renal function recovery and death within 30 days in AKI patients.Results:The rate of poor renal function in the holiguria group after CRRT was 42.1％,and the mor-tality rate within 30 days was 23.7％,which was significantly higher than that in the non-oliguria group(P＜0.01).Multivariate logistic regression analysis showed that higher APACHE Ⅱ score,less 24 h urine volume,and higher brain natriuretic peptide(BNP)before treatment were independent risk factors for poor renal function recovery in AKI patients(P＜0.05).Advanced age,less 24 h urine volume,higher APACHE Ⅱ score before treatment,and poor renal function recovery were indepen-dent risk factors for death within 30 days in AKI patients(P＜0.05).Conclusion:CRRT should be initiated at higher urine volume and lower APACHE Ⅱ score to improve renal function recovery and reduce mortality in patients with AKI in the non-ICU department.
Continuous Renal Replacement TherapyAcute Kidney InjuryTiming of Treat-mentRecovery of Renal FunctionMortality Rate
NETL
NSTL
万方数据
维普
