Effects of repetitive transcranial magnetic stimulation on neurotransmitters,neurological and cognitive function in patients with acute cerebral infarction
Objective:To investigate the changes of neurotransmitters in the brain after acute cerebral infarc-tion and the effects of repeated transcranial magnetic stimulation(rTMS)on neurotransmitters,neuro-logical function,and cognitive function.Methods:A total of 200 patients with acute cerebral infarction and cognitive impairment admitted from January 2017 to January 2019 were randomly divided into the control group and rTMS group,with 100 patients in each group.The control group received conven-tional treatment such as antiplatelet therapy and lipid regulation,and the rTMS group was treated with rTMS in addition to conventional treatment.N1HSS were used to evaluate the neurological deficit at admission and on the 3rd,14th,and 28th days after onset.The power of six neurotransmitters includ-ing glutamate(Glu),gamma-aminobutyric acid(GABA),dopamine(DA),5-hydroxytryptophan(5-HT),norepinephrine(NE),and acetylcholine(Ach)were measured by encephalofluctuograph.Cog-nitive function was assessed by the Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE)at admission and on the 14th and 28th days after onset.Results:After acute ce-rebral infarction,there was a neurotransmitter imbalance in the brain.The specific characteristics were as follows:the power of six neurotransmitters showed an upward trend in the first three days after the onset and reached the peak on the third day,then showed a continuous downward trend on the 14th and 28th days;on the 14th day,the scores of Glu,DA,5-HT,and NE power,and NIHSS in the rTMS group were lower than those in the control group,the scores of GABA power and MMSE were higher than those in the control group;On the 28th day,the scores of Glu,DA,5-HT,NE,ACh power and NIHSS were lower than those in the control group,the scores of GABA power,MoCA and MMSE were higher than those in the control group.Conclusion:There was a neurotransmitter imbalance in the brain after acute cerebral infarction,and rTMS treatment can effectively improve the neurotrans-mitterimbalance,relieve neurological impairment,and improve cognitive function.
Acute Cerebral InfarctionRepetitive Transcranial Magnetic StimulationNeu-rotransmitterCognitive Function
NETL
NSTL
万方数据
维普
