摘要
肥胖是肿瘤发展的危险因素,与多种肿瘤的不良预后有关,脂代谢紊乱成为探索肥胖症和肿瘤疾病内在联系的关键.脂肪酸结合蛋白(FABPs)是一系列水溶性小蛋白质,主要负责长链脂肪酸的转运和代谢,同时也可以作为转录因子在细胞核内发挥作用.脂肪组织来源的脂肪酸结合蛋白主要包括FABP4和FABP5,它们被鉴定为多种恶性肿瘤的致癌基因.本文总结了FABP4和FABP5在肿瘤疾病发生发展中的作用,重点介绍了FABP4和FABP5对肿瘤免疫微环境的调控机制,阐述了以FABP4和FABP5为治疗靶点的最新研究进展.
Abstract
There is evidence that obesity increases cancer risk and is associated with poor prognosis among a variety of types of tumors.Lipid metabolic disorders may be a breakthrough in understanding the intrinsic link between obesity and tumors.Fatty acid binding proteins(FABPs)are a series of small water-soluble proteins that are primarily responsible for transporting long-chain fatty acids and functioning as transcription factors.Adipose tissue-derived FABP4 and FABP5 have been defined as important oncogenic drivers of multiple malignancies.This review summarizes the effects of FABP4 and FABP5 in tumor progression with a focus on tumor immunity.We conclude with thoughts on recent advances in tumor therapy based on the new understanding of FABP4 and FABP5.
NETL
NSTL
维普
万方数据