Objective:To study the effect of continuous oral aspirin on the risk of bleeding and thromboem-bolism after minimally invasive thoracic surgery in elderly patients.Methods:A retrospective analysis was performed on 60 elderly patients who underwent minimally invasive thoracic surgery and took as-pirin for a long time in Zhongnan Hospital of Wuhan University from January 2015 to May 2022.Thir-ty patients(experimental group)stopped taking aspirin before the operation and used low molecular weight heparin as an anticoagulant,while another thirty patients(control group)continued to take aspi-rin before the operation.All patients were examined by thromboelastography(TEG)before the opera-tion.Intraoperative blood loss,postoperatively drainage at the end of 24 h and 72 h,length of hospital stays,and thrombotic complications were compared between the two groups.Results:There was no significant difference between the experimental and the control group in intraoperative bleeding,drain-age volume at the end of 24 h and 72 h after operation,incidence of thrombotic complications,and length of hospitalization(P>0.05).Conclusion:For the elderly patients who did not stop taking aspi-rin during the perioperative period,the amount of bleeding and the incidence of thrombosis complica-tions did not increase during thoracic minimally invasive surgery.Aspirin may not be stopped when TEG reasonably monitors the blood coagulation function.