血清隐球菌荚膜多糖抗原检测在肺隐球菌病中的诊断价值
Diagnostic value of detection of serum cryptococcal capsular polysaccharide antigen in pulmonary cryptococcosis
荣玉琼 1潘珍珍 1朱苗娟 1杨炯1
作者信息
- 1. 武汉大学中南医院呼吸与危重医学科 湖北 武汉 430071
- 折叠
摘要
目的:评价血清隐球菌荚膜多糖抗原(CrAg)检测在疑似肺隐球菌病(PC)患者中的诊断价值,并分析影响其结果的因素.方法:以病理检查为金标准,选取2020年1月至2022年11月疑似PC的患者,均行血清隐球菌荚膜抗原检测.结果:在234例疑似PC的患者中,最终确诊为PC的患者127例,非PC患者107例.血清CrAg检测诊断肺隐球菌病的灵敏度为65.4％,特异度86.0％,其曲线下面积(AUC)[95％置信区间(95％CI)]为0.756(0.693 6,0.819 7).CrAg阴性和阳性患者的年龄、基础疾病史、病灶类型及分布部位差异有统计学意义(P＜0.05).结论:血清CrAg检测有很好的特异度,有助于筛查疑似肺隐球菌病的患者,以便早期诊断及指导治疗.
Abstract
Objective:To evaluate the diagnostic value of serum cryptococcal capsular polysaccharide anti-gen(CrAg)in patients with suspected pulmonary cryptococcosis(PC)and analyze the factors influenc-ing the results.Methods:With pathological examination as the gold standard,the patients who were suspected of PC from January 2020 to November 2022 were selected.All patients were tested for se-rum CrAg.Results:Among the 234 patients suspected of PC,127 patients were finally diagnosed with PC and 107 patients were not.The sensitivity and specificity of serum CrAg in the diagnosis of PC were 65.4％and 86.0％,and its area under the curve(AUC)value(95％confidence interval)was 0.756(0.693 6,0.819 7).Significant differences were found in age,basic diseases,and types and dis-tribution of focal infections between the positive CrAg group and the negative CrAg group(P＜0.05).Conclusion:The detection of serum CrAg has a good specificity,which helps screen patients suspect-ed of pulmonary cryptococcosis for early diagnosis and treatment guidance.
关键词
肺隐球菌病/隐球菌荚膜多糖抗原/灵敏度/特异度/受试者特异曲线Key words
Pulmonary Cryptococcosis/Cryptococcus Capsular Polysaccharide Antigen/Sensi-tivity/Specificity/Subject Specific Curve引用本文复制引用
出版年
2024
NETL
NSTL
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