Objective:To compare the clinical application value of contrast-enhanced ultrasound(CEUS)and conventional two-dimensional ultrasound guidance in soft tissue tumor puncture biopsy.Methods:Retrospective analysis of sixty-nine patients with soft tissue tumors who were divided into 32 cases in the two-dimensional ultrasound group and 37 cases in the CEUS group according to the different guid-ance methods.Using the postoperative pathological results as the gold standard,the diagnostic accura-cy,sensitivity,specificity,positive predictive value,and negative predictive value of the two groups in identifying benign and malignant soft tissue tumors were calculated and compared.The reciver op-erating characteristic(ROC)curves for the diagnosis of soft tissue tumors with conventional ultrasound and CEUS-guided puncture biopsy were plotted,and the area under the curve(AUC)was calculated.Results:There was no statistically significant difference between the two groups in terms of gender,age,lesion location,and lesion diameter.The puncture accuracy rates were 69.57%and 92.85%in the two-dimensional ultrasound group and CEUS group,respectively,with statistically significant dif-ference(P<0.05).The mean of puncture times were 5.0 per person in conventional ultrasound group and 4.6 per person in the CEUS group,without statistically significant difference(P>0.05).The sensitivity,specificity,positive predictive value,and negative predictive value for identifying benign and malignant tumors in both groups were 100%,81.25%,70%,and 100%,respectively,versus 100%,93.75%,92.3%,and 100%,respectively,without statistically significant difference(P>0.05).The AUC was 0.825 in the conventional ultrasound group and 0.941 in the CEUS group with statistically significant difference(P<0.05).Conclusion:For soft tissue tumors with large size and heterogeneity,CEUS could be adopted to effectively plan the puncture path,accurately and safely guide the puncture,and perform sample biopsy in the most representative area,which can achieve higher diagnostic accuracy and provide more effective clinical information than conventional ultra-sound.The CEUS is a minimally invasive and efficient means of real-time visualization.
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