Effect of preconditioning with penehyclidine hydrochloride on the respiratory function of pregnant women undergoing combined spinal-epidural anesthesia in cesarean section
Objective:To investigate the effect of pentylenethyclidine hydrochloride on the respiratory func-tion of pregnant women who underwent combined spinal-epidural anesthesia.Methods:Eighty preg-nant women scheduled for cesarean section underwent combined spinal-epidural anesthesia in Yichang Central People's Hospital from November 2022 to March 2023 were enrolled,and were divided into the saline group(group N)(n=40)and pentylenethyclidine hydrochloride group(group P)(n=40)random-ly.The patients in group P received intravenous pentylenethyclidine hydrochloride at 0.01 mg/kg,while group N received an equivalent volume of normal saline 30 min before anesthesia.The systolic blood pressure(SBP),diastolic blood pressure(DBP),mean diastolic pressure,heart rate(HR),and pulse oxygen saturation(SPO2)were recorded at different time points including T0(before administra-tion),T1(immediately after successful anesthesia),T2(immediately after fetal extraction),T3(5 min after fetal extraction),and T4(20 min after fetal extraction);arterial oxygen partial pressure and arterial carbon dioxide partial pressure at T0,T3 and T4 were recorded.The incidence rate of dyspnea and oth-er adverse events of pregnant women and the birth status of newborns was recorded.Results:The arte-rial oxygen partial pressure(PaO2)of the two groups at T3 and T4 was higher than that at T0(P<0.05)respectively;the arterial PaO2 at T3 and T4 in group P was higher than that in the saline group(P<0.05).The incidence of intraoperative dyspnea in group P was lower than in group N(P<0.05).The incidences of shivering,nausea and vomiting,and other complications in group P were lower than in group N(P<0.05).There was no statistical difference in neonatal birth status indicators between the two groups(P>0.05).Conclusion:Pretreatment with pentylequidine hydrochloride has certain bene-fits for the respiratory function of full-term pregnant women undergoing combined spinal-epidural anes-thesia in cesarean section and does not affect the outcome of newborns.
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