Objective:To investigate the predictive value of plasma superoxide dismutase(SOD),cystatin C(CysC)and kidney injury molecule-1(KIM-1)levels on the risk of acute kidney injury(AKI)in elder-ly patients with sepsis.Methods:The number of 162 patients admitted to The Fourth Affiliated Hos-pital of Nanjing Medical University and diagnosed with sepsis were selected as the research objects.According to the presence or absence of AKI during hospitalization,they were divided into 114 cases in the AKI group and 48 cases in the non-AKI group.The predictive value of plasma SOD,CysC and KIM-1 levels in the risk of AKI in elderly patients with sepsis was analyzed.Results:The levels of plasma CysC and KIM-1 at timepoints of 24 h,36 h and 72 h after diagnosis of sepsis in the AKI group were higher than those in the non-AKI group,and the level of SOD was lower than that in the non-AKI group(P<0.05);compared with those at 0 h,the levels of plasma CysC and KIM-1 in the AKI group increased from 24 h to 72 h,while the level of SOD decreased(P<0.05).The area under the ROC curve(AUC)of the combination of SOD,CysC and KIM-1 in predicting the occurrence of AKI in elderly patients with sepsis was 0.948,while the specificity was 93.7%,and the sensitivity was 84.2%.KIM-1 was an independent risk factor for AKI in elderly patients with sepsis(P<0.05),and SOD was a protective factor for AKI in elderly patients with sepsis(P<0.05).Conclusion:The plasma CysC and KIM-1 levels increase and SOD level decreases in elderly patients with sepsis com-plicated by AKI.Combined detection of plasma SOD,CysC and KIM-1 can early predict the risk of AKI in elderly patients with sepsis and has clinical reference values.
Senile SepsisSuperoxide DismutaseCystatin CKidney Injury Molecule-1Acute Kidney InjuryPredictive Value
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