Objective:To explore the correlation between the change of neonatal coagulation function,se-verity of neonatal acute respiratory distress syndrome(ARDS),and pulmonary ventilation/ventilation function.Methods:Full-term ARDS children admitted to the Intensive Care Unit of Renmin Hospital of Wuhan University from June 2020 to June 2022 were selected as the case group,which were divid-ed into mild,moderate,and severe groups according to the oxygenation indexes,and 50 healthy term children born at the same period were selected as the control group.Blood samples were taken on the first day and seventh day of hospitalization.The C-reactive protein(CRP),platelet count(PLT),arte-rial partial pressure of oxygen(PaO2),arterial blood carbon dioxide partial pressure(PaCO2),and co-agulation functions,including fibrinogen(FBG),D-dimer(D-D),prothrombin time(PT),and activat-ed partial thrombin time(APTT)were compared.Results:Compared with those in the control group,PLT and FBG in the case group were decreased(P<0.05);PT,APTT,D-D,and CRP were signif-icantly increased(P<0.05);PaO2 was decreased while PaCO2 was increased(P<0.05).Further-more,from low to high depending on the severity of disease,PLT,FBG,and PaO2 decreased while the PT,APTT,D-D,CRP,and PaCO2 increased(P<0.05).Multivariate analysis showed the APTT,PT,and D-D were positively correlated with PaO2 and negatively correlated with PaCO2.The APTT,PT,and D-D levels,neonatal asphyxia,and neonatal sepsis were risk factors for AR-DS.Conclusion:Blood coagulation function plays an important role in the pathological process of neo-natal ARDS.It can be used for early diagnosis as well as the indicators of severity and prognosis of the disease.
NETL
NSTL
万方数据
