摘要
目的:探讨癫痫儿童共患注意缺陷多动障碍(ADHD)的临床特点,分析癫痫相关因素与ADHD之间的关系,为临床诊治提供参考依据.方法:回顾性收集2018年6月至2021年6月在武汉大学人民医院儿科住院部90例癫痫患儿的详细临床资料,采用美国精神医学学会修订的《精神障碍诊断与统计手册(第5版)》中ADHD诊断标准进行评估,其中90例癫痫患儿中35例为癫痫共患ADHD患儿(38.9%),55例为单纯癫痫患儿,通过单因素分析和多因素Logistic回归分析确定癫痫共患ADHD的危险因素.结果:癫痫共患ADHD组与单纯癫痫组在性别、癫痫首次发病年龄、抗癫痫药物多药联合、癫痫发作是否控制以及是否有热性惊厥病史差异有统计学意义(χ2= 6.194;7.011;12.735;13.502;5.440,P<0.05),而癫痫病程、发作类型、单一应用不同抗癫痫药及脑电图是否恢复正常与二者共患无统计学意义(P>0.05).结论:男性患儿、癫痫首次发病年龄小于3岁、抗癫痫药物多药联合、癫痫控制与否以及热性惊厥病史是癫痫共患ADHD的危险因素.
Abstract
Objective:To investigate the clinical characteristics of epilepsy children with attention deficit hy-peractivity disorder(ADHD),analyze the relationship between epilepsy-related factors and ADHD,and provide a reference basis for clinical diagnosis and treatment.Methods:Detailed clinical data of 90 children with epilepsy in the Renmin Hospital of Wuhan University were studied retrospectively from June 2018 to June 2021,and ADHD diagnosis criteria according to the Diagnostic and Statistical Manual of Mental Disorders(DSM-5)revised by the American Psychiatric Association were used.Among the 90 children with epilepsy,35(38.9%)had epilepsy with ADHD,and 55 had epilepsy alone.The risk factors for co-occurring ADHD in epilepsy were determined by univariate analysis and multivariate logistic regression analysis.Results:There were statistically significant differences be-tween the two groups in age at the first onset of epilepsy,multiple combinations of antiepileptic drugs,whether seizures were controlled,and whether there was a history of febrile convulsions(χ2=6.194,7.011,12.735,13.502,5.440,P<0.05).However,there were no statistically significant differences in duration of epilepsy,seizure type,single application of different antiepileptic drugs,and whether EEG returned to normal(P>0.05).Conclusion:The risk factors for co-occurring ADHD in epilepsy children were male,age at first seizure onset less than 3 years,multiple combinations of anti-epileptic drugs,seizure control,and history of febrile convulsion.
基金项目
武汉大学医学腾飞计划资助项目(TFLC2018001)
NETL
NSTL
万方数据