Most cardiovascular diseases are fatal to patients.These diseases are generally irreversible,the focus of treatment is on symptomatic treatment to delay the progression of the disease.Therefore,developing new therapies is crucial.Lipid nanoparticles(LNPs)have the general advantages of nano size and lipid compounds,and they can overcome the inherent defects of other targeted carriers,so they have the potential for clinical application in cardiovascular diseases.This article reviews the latest progress in the application of LNPs in various cardiovascular diseases.