Construction and validation of a prognostic model of angiogenesis-related genes in hepatocellular carcinoma
Objective:To construct and validate a prognostic model of angiogenesis-related genes in hepato-cellular carcinoma(HCC).Methods:Differentially expressed genes were obtained by differential analysis of the TCGA-LIHC dataset.Then the co-expression network was constructed based on them to screen the modules related to HCC's proliferation,metastasis,and vascular invasion.Then module genes and angiogenesis-related genes were intersected to obtain candidate genes.Finally,the prognos-tic models were constructed by univariate and multivariate Cox regression.And further,the perfor-mance of the model and its clinical relevance was evaluated.ICGC data were used for validation.Results:Eight genes related to angiogenesis were selected to construct the prognostic model.The ROC curve showed that patients with higher risk scores had shorter survival times.The area under the curve(A UC)of 1,2,and 3 years were 0.797,0.743,and 0.711,respectively,and it indicated that the model could be used for predicting independent prognostic factors for HCC.Conclusion:Our prognostic model can predict the prognosis of HCC patients,which can be used for clinical reference and provide a new idea for the angiogenesis mechanism in HCC.
Hepatocellular CarcinomaAngiogenesisPrognostic Model
NETL
NSTL
万方数据
