Ambient ozone exposure and the severity of coronary heart disease:A predicting role of aspartate aminotransferase
Objective:To explore the relationship between ambient ozone exposure and the severity of coro-nary heart disease(CHD)and the potential role of aspartate aminotransferase(AST).Methods:We in-cluded 2 537 CHD patients who had undergone coronary angiography from 2016 to 2021 at the Zhong-nan Hospital of Wuhan University.According to the SYNTAX score,they were categorized into low(0-22)or high(≥23)SYNTAX score groups.The logistic regression was used to fit the association between ozone exposure and the severity of CHD.Linear regression was performed to explore the re-lationship between ozone exposure and biochemical indicators.Mediation analysis was performed to examine the potential effect of AST in the association between ozone exposure and CHD severity.Results:As the ozone concentration increased,the risk of suffering from more severe CHD increased(OR=1.072,P＜0.05).AST(β=3.622,P＜0.05)was positively correlated with ozone exposure in elderly patients.Mediation analysis showed that AST mediated 13.1％(P=0.045)of the ozone-SYNTAX score association.Conclusion:This study indicated that long-term ozone exposure was as-sociated with the severity of CHD,and serum AST might be used as a predictor of the severity of CHD.
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