Objective:To investigate the effects of different doses of femoston combined with oryzanol on sex hormones and oxidative stress in patients with menopause syndrome.Methods:A total of 120 menopause syndrome patients admitted to the hospital from August 2020 to August 2021 were select-ed and randomly divided into three groups as groups A,B,and C,with 40 cases in each.Group A was given oryzanol,group B was given conventional doses of femoston combined with oryzanol,while Group C was given low-dose femoston combined with oryzanol.The clinical curative effect was compared between the three groups in the serum indices:sex hormones,such as follicle-stimulating hormone(FSH),estradiol(E2),and luteinizing hormone(LH);lipid levels,such as triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDLC),and low-density lipoprotein cho-lesterol(LDLC);oxidative stress indices,such as malondialdehyde(MDA)and superoxide dismutase(SOD);and adverse events.Results:The total effective rate between the three groups was significant-ly different(P＜0.05).There were significant differences in FSH,E2,and LH levels between the three groups after treatment(P＜0.05).The levels of FSH and LH in groups B and C were signifi-cantly lower than those in group A(P＜0.05).The level of E2 in group A was significantly higher than that in group A(P＜0.05).The levels of TG,TC,HDLC,and LDLC in the three groups changed significantly after treatment(P＜0.05).The levels of TG,TC,and HDLC in groups B and C were significantly lower than in the group A(P＜0.05),while the level of LDLC was significantly higher(P＜0.05).There was no significant difference in the levels of TG,TC,HDLC,and LDLC between group B and group C(P＞0.05).After treatment,the levels of MDA and SOD in the three groups were significantly different(P＜0.05).MDA levels in groups B and C were significantly lower than those in group A(P＜0.05).The levels of SOD in group A were significantly higher than that in group B(P＜0.05).The total incidence of adverse events in the three groups was significantly differ-ent(P＜0.05),and the incidence in group B was the highest among the three groups(P＜0.05).Con-clusion:Compared with oryzanol alone,femoston combined with oryzanol has better clinical efficacy in the treatment of patients with menopause syndrome,which can improve their sex hormone and blood lipid levels and reduce the stress response.However,the effect of low-dose femoston is equiva-lent to that of conventional dose,with fewer adverse events.
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