甘油三酯-葡萄糖指数与内脏脂肪面积联合检测对2型糖尿病早期外周血管病变的预测价值
Predictive value of combined detection of triglyceride glucose index and visceral fat area in the diagnosis of early peripheral vascular disease in type 2 diabetes mellitus
卢新妍 1林萱 2崔静 2王强 3郭红艳 2邓春霞 4徐嘉蔚 1丁家豪 5占水朦 5夏芳5
作者信息
- 1. 武汉科技大学附属华润武钢总医院内分泌科 湖北 武汉 430080;武汉科技大学医学院 湖北 武汉 430062
- 2. 武汉科技大学附属华润武钢总医院内分泌科 湖北 武汉 430080
- 3. 武汉科技大学医学院湖北省职业病危害识别与控制重点实验室感染免疫与肿瘤微环境研究所湖北 武汉 430065
- 4. 广西壮族自治区人民医院内分泌科 广西 南宁 530021
- 5. 武汉科技大学医学院 湖北 武汉 430062
- 折叠
摘要
目的:探讨甘油三酯-葡萄糖指数(TyG)、内脏脂肪面积(VFA)对2型糖尿病(T2DM)患者发生早期外周血管病变(PVD)的预测价值.方法:回顾性分析符合纳入标准437例T2DM患者,根据是否合并外周血管病变将患者分为T2DM合并PVD患者和T2DM无PVD患者.使用多因素Logistic回归分析比较两组间指标的差异,采用受试者工作特征(ROC)曲线评估TyG、VFA以及TyG+VFA联合诊断对T2DM早期PVD的预测价值.结果:排除混杂因素干扰后,多因素Logistic回归分析结果显示:VFA和TyG指数是影响T2DM PVD的独立危险因素(P＜0.05). ROC曲线分析显示,TyG+VFA联合诊断的ROC曲线下面积最大,为0.863,诊断价值更大.结论:TyG、VFA与T2DM早期PVD的发生密切相关,二者联合诊断可提高预测价值.
Abstract
Objective:To explore the predictive value of the triglyceride-glucose index(TyG)and visceral fat area(VFA)in early peripheral vascular disease(PVD)in patients with type 2 diabetes mellitus(T2DM).Methods:A retrospective analysis was conducted on 437 T2DM patients who met the inclu-sion criteria.Patients were divided into T2DM patients with PVD and T2DM patients without PVD.Multiple logistic regression analysis was used to compare the differences in indicators between the two groups,and receiver operating characteristic(ROC)curves were used to evaluate the predictive value of TyG,VFA,and TyG+VFA combined diagnosis for early PVD in T2DM.Results:After exclud-ing confounding factors,multivariate logistic regression analysis showed that VFA and TyG indexes were independent risk factors for PVD in T2DM(P＜0.05).ROC curve analysis showed that the combined diagnosis of TyG+VFA had the largest area under the ROC curve,which was 0.863,indi-cating a greater diagnostic value.Conclusion:TyG and VFA are closely related to the occurrence of early PVD in T2DM,and their combined diagnosis can improve the predictive value.
关键词
外周血管疾病/2型糖尿病/甘油三酯-葡萄糖指数/内脏脂肪Key words
Peripheral Vascular Disease/Type 2 Diabetes Mellitus/Triglyceride-Glucose In-dex/Visceral Fat Area引用本文复制引用
基金项目
湖北省微循环学会人才培养专项科研基金(HBWXH20181-6)
出版年
2024
NETL
NSTL
万方数据