Objective:To investigate the effects of benzodiazepines in nulliparous women with an unfavor-able cervix at term undergoing induction of labor by dinoprostone for labor analgesia.Methods:A to-tal of 100 nulliparous women who planned for vaginal delivery and had a Bishop score of＜3 were di-vided into an observation group(n=47)and a control group(n=44)by envelop randomization.In the observation group,10 mg of benzodiazepines were injected intravenously for 2 hours after removal of dinoprostone,and then oxytocin was started to initiate uterine contractions.In the control group,oxy-tocin was directly used to induce uterine contractions after the removal of dinoprostone.When dilation of the cervix was 3 cm,the dural puncture epidural block was used for labor analgesia in the above two groups.The first stage of labor time,total labor time,the rate of vaginal delivery,postpartum hemor-rhage of nulliparous women,and the incidence of neonatal asphyxia between the two groups were compared.Results:Compared with that respectively in the control group,the time for both the first stage and the total stage of labor was significantly shorter in the observation group(P=0.004);the vaginal delivery rate was 74.5％in the observation group,which was significantly higher than 54.5％in the control group(P=0.047).At the same time,there was no significant difference in neonatal as-phyxia rate between the two groups(P=1.000).Conclusion:The use of benzodiazepines could short-en the labor time of nulliparous women at term undergoing induction of labor by dinoprostone and has no adverse effects on delivery outcomes.
DinoprostoneBenzodiazepinesFullterm BirthsNulliparityInduction of Labor
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