Effects of different doses of erythropoietin on myocardial injury and brain function in children with congenital heart disease after interventional therapy
Objective:To investigate the effects of different doses of erythropoietin(EPO)on myocardial in-jury and brain function indexes in children with congenital heart disease after interventional therapy.Methods:The clinical data of children with congenital heart disease admitted to our hospital from April 2020 to April 2022 were retrospectively analyzed.All children received interventional therapy.According to different doses of EPO,the children were divided into a low-dose group(n=30)and a high-dose group(n=34).The low-dose group was treated with 100 U/kg EPO,and the high-dose group was treated with 200 U/kg EPO.Surgery-related indicators,myocardial injury indicators,type Ⅰ collagen carboxy-terminal peptide(ICTP),ischemia modified albumin(IMA),cystatin C(Cys-C),creatine kinase isoenzyme(CK-MB),and cardiac troponin(cTnI),before and after treatment were compared between the two groups.Brain function indexes,neuron-specific enolase(NSE)and brain-specific protein(S-100β),and adverse reactions were compared before operation(T0),at the end of operation(T1),2 hours after operation(T2)and 24 hours after operation(T3).Results:There were no significant differences in operation time,cardiopulmonary bypass time,and aortic occlusion time between the two groups(P>0.05).The 24-hour drainage volume after operation,the duration of postoperative auxiliary ventilation,and the length of hospital stay in the high-dose group were lower than those in the low-dose group(P<0.05).Before treatment,the two groups had no significant dif-ference in myocardial injury indexes(P>0.05),but after treatment,the levels of ICTP and IMA in the high-dose group were lower than those before treatment and the low-dose group(P<0.05),the levels of Cys-C in the high-dose group were higher than those before treatment and the low-dose group(P<0.05),the levels of CK-MB and cTnI in the high-dose group were higher than those before treat-ment(P<0.05)and lower than those in the low-dose group(P<0.05).At T0 and T3,the two groups had no significant differences in NSE and S-100β levels(P>0.05).At T1 and T2,the levels of NSE and S-100β in the two groups were higher than those at T0(P<0.05),and those in the low-dose group were higher than those in the high-dose group(P<0.05).The incidence of adverse re-actions in the low-dose group was lower than that in the high-dose group,but there was no significant difference between the two groups(16.67％vs 26.47％,P>0.05).Conclusion:Different doses of EPO can achieve good effects in the treatment of children with congenital heart diseases,and the ef-fect of high doses is better,which can reduce myocardial injury and improve brain function,without in-creasing adverse reactions.
Different DosesErythropoietinCongenital Heart DiseaseInterventional Thera-pyMyocardial InjuryBrain Function
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