Objective:To compare the feasibility,safety,and efficacy of hybrid and complete thoraco-scopic surgery in the treatment of esophageal carcinoma.Methods:A retrospective analysis was made from January 2018 to January 2020 on the clinical data of patients who received right thoracic esophageal cancer resection,and the patients were divided into hybrid or complete laparoscopic groups.Results:The operation time of the complete laparoscopic group was longer than that of the hy-brid laparoscopic group,as(455±79)min vs(439±76)min,P=0.035.More intraoperative bleeding,longer chest drainage time,peritoneal drainage time,ICU hospitalization,and postopera-tive hospitalization time were found in the hybrid laparoscopic group as compared with those in the complete laparoscopic group.As for histopathology,lymph node dissection stations and the lymph node numbers in the complete laparoscopic group were more than those in the hybrid laparoscopic group as(7.8±2.4)vs(7.3±2.1),P=0.022,and(19.6±4.3)vs(18.5±3.2),P=0.003,respec-tively.The postoperative complication rate in the complete laparoscopic group was less than that in the hybrid laparoscopic group(7.4%vs 13.6%,P=0.049).Conclusion:Total endoscopic radical resection of esophageal cancer has the advantages of less bleeding,quick postoperative recovery,few-er postoperative complications,less impact on lung function,and higher postoperative quality of life.