Objective:To analyze the levels of serum mucin 1(MUC1)and CD5 antigen like protein(CD5L)in patients with transfusion related acute lung injury and their prognostic factors,and to ex-plore the predictive value of serum MUC1 and CD5L levels for prognosis.Methods:A retrospective study was conducted on 132 patients with transfusion-related acute lung injury who were treated in The First Hospital of Zhangjiakou from August 2021 to June 2023,according to their prognosis,the patients were separated into a good prognosis group(87 cases)and a poor prognosis group(45 cases).General clinical data of the two groups were collected.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the levels of serum MUC1 and CD5L;χ2 test or t-test was applied to compare the general clinical data and serum levels;R language cor function was applied to analyze the correla-tion between the two serum indicators'levels and prognosis;multivariate Logistic regression was ap-plied to analyze the influencing factors of prognosis,receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum MUC1 and CD5L levels for prognosis.Results:The disease severity,blood glucose,and MUC1 serum levels in the poor prognosis group were higher than those in the good prognosis group,while the CD5L serum level was lower in the poor prognosis group(all P<0.05).There was an obvious negative correlation between the levels of serum MUC1 and CD5L in patients,and between the levels of CD5L and prognosis,the correlation between MUC1 and prognosis was positive(all P<0.05).Logistic regression analysis showed that the CD5L serum level was a protective factor for poor prognosis in patients,while the APACHE Ⅱ score and MUC1 serum level were risk factors for poor prognosis of the patients(both P<0.05).ROC curve analysis showed that levels of serum MUC1 and CD5L could be used as predictive indicators for the prognosis of the patients with transfusion related acute lung injury,and the predictive value of their combined detection was higher(P<0.05).Conclusion:The levels of serum MUC1 and CD5L in pa-tients with transfusion related acute lung injury are closely related to the prognosis,and the combina-tion of the two has higher predictive value for the prognosis.
Transfusion Related Acute Lung InjuryMucin 1CD5 Antigen Like ProteinSe-verity of ConditionPredictive Value
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