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妊娠期糖尿病对产妇及新生儿结局的影响

Influence of pregnancy diabetes mellitus on neonatal outcome

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目的:研究妊娠期糖尿病(GDM)对产妇并发症及新生儿结局的影响,同时观察口服葡萄糖耐量试验(OGTT)不同时点血糖指标异常对妊娠结局的影响.方法:收集2018年1月至2019年12月住院GDM产妇(观察组)与同期住院无GDM产妇(对照组)的临床资料.比较两组的一般资料、产妇并发症(高血压疾病、产后出血、分娩方式)及新生儿结局(出生时窒息、早产儿、巨大儿、新生儿呼吸窘迫综合征、高胆红素血症、新生儿低血糖、心脏结构异常、新生儿坏死性小肠结肠炎、红细胞增多症).结果:观察组与对照组的一般资料比较,两组产前的体质量指数(BMI)差异具有统计学意义(P<0.05).GDM组的高血压发生率、剖宫产率均高于非GDM组产妇(P<0.05).空腹血糖及餐后血糖均异常组所分娩新生儿巨大儿发生率高于仅空腹血糖升高或仅糖耐量异常组.结论:GDM孕产妇不良孕产结局发生率高,妊娠期高血压疾病、剖宫产及新生儿不良结局等增多,且空腹血糖异常合并有餐后1 h或2 h异常者巨大儿发生风险更高.因此,加强对GDM孕产妇的分类管理和精准治疗非常重要.
Objective:To study the influence of pregnant women with gestational diabetes(GDM)on ma-ternal complications and neonatal outcomes,and to observe the influence of abnormal blood glucose indicators at different time points of oral glucose tolerance test(OGTT)on pregnancy outcomes.Methods:A total of 233 newborns pregnant women with GDM(observation group)from January 2018 to December 2019 were collected.In the control group,233 mothers without abnormal blood glucose during pregnancy were selected.The general data,maternal complications(hypertension,postpartum hemorrhage,postnatal mode),and neonatal outcomes(such as asphyxia at birth,prema-ture infants,macrosomia,neonatal respiratory distress syndrome,hyperbilirubinemia,neonatal hypo-glycemia,cardiac structural abnormalities,neonatal necrotizing enterocolitis,and polycythemia)were compared between the two groups.Results:Comparing the general data between the observation and the control group,there was a statistical difference in the prenatal BMI(P<0.05).The incidences of hypertension and cesarean section in the GDM group were higher than those in the non-GDM group(P<0.05).The incidence of macrosomia was the highest in the patients with both abnormal fasting glucose and OGTT results.Conclusion:The incidence of adverse pregnancy outcomes in GDM preg-nant women is high,with an increase in hypertensive disorders of pregnancy,cesarean section rates,and neonatal adverse outcomes.Moreover,the risk of macrosomia is higher in neonates from mothers with fasting hyperglycemia combined with postprandial 1-hour or 2-hour abnormalities.Therefore,the classified management and precise treatment are importan for pregnant women with GDM.

Gestational Diabetes MellitusNeonatal OutcomesAbnormal Blood Glucose

周玉、吴素英、彭芬

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湖北民族大学附属民大医院新生儿科 湖北 恩施 445000

妊娠期糖尿病 新生儿结局 血糖异常

湖北省教育厅科学研究计划项目

D20171901

2024

武汉大学学报(医学版)
武汉大学

武汉大学学报(医学版)

CSTPCD
影响因子:0.959
ISSN:1671-8852
年,卷(期):2024.45(7)
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