Objective:To study the clinical features,outcomes,and risk factors of death in the maintenance hemodialysis(MHD)patients infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and to provide a reference for their diagnosis and treatment.Methods:This study retrospectively analyzed the MHD patients in Zhongnan Hospital of Wuhan University from December 7,2022,to January 31,2023.The clinical data of MHD patients with the Omicron variant infection were collected.The univariate and multivariate logistic regression analyses were used to investigate the factors that might influence mortality.Results:A total of 183 cases were included in the study,175 cases were infected,and the infection rate was 95.6%.The infected patients were di-vided into two subgroups:the death group(n=22)and the survival group(n=153),with a mortality rate of 12.6%.The most common clinical symptoms were fever(62.9%)and cough(61.7%),and a few patients had a sore throat,diarrhea,antiphrasis,and nervous system manifestations.There was no significant difference in clinical symptoms between the two subgroups(P>0.05).Univariate analy-sis showed that the risk factors for death included older age,male,and histories of previous strokes and severe pulmonary infections(P<0.05).Multivariate logistic regression analysis revealed that age and pulmonary infections were independent risk factors of mortality(P<0.05).Age,pulmonary in-fections,and a combination of the two were predictive indicators,and their area under the curve(AUC)for predicting death were 0.771,0.862,and 0.903,respectively.Conclusion:The most common clinical manifestations of Omicron variant infections in maintenance hemodialysis patients are fever and cough.Older age and increased area of pneumonia were independent risk factors for mortali-ty.ROC curve showed that age combined with pulmonary infections exerted a good predictive value for death.
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