血浆置换联合双重血浆分子吸附系统人工肝在急性肝功能衰竭患者中的应用效果
Effect of plasma exchange combined with double plasma molecular absorber system artificial liver in patients with acute liver failure
孙雯 1王倩 1潘露 1魏文娇1
作者信息
- 1. 武汉市第三医院重症医学科 湖北 武汉 430070
- 折叠
摘要
目的:探讨血浆置换(PE)联合双重血浆分子吸附系统(DPMAS)人工肝模式在急性肝功能衰竭(AHF)患者中的应用效果.方法:随机选取2019年1月-2022年1月80例AHF患者,分为对照组与观察组各40例.对照组采用PE模式治疗,观察组联合应用DPMAS模式进行治疗,随访3个月,对比两组患者血常规、凝血功能及肝肾功能变化,观察临床基本指标及预后差异,统计治疗期间相关并发症发生情况.结果:观察组血常规、凝血功能、肝肾功能及预后情况均明显优于对照组(P＜0.05),观察组临床基本指标明显低于对照组(P＜0.05),两组患者并发症发生率无明显差异(P＞0.05).结论:PE+DPMAS人工肝模式在AHF患者中具有积极的应用效果,对于改善患者凝血及肝肾功能,提高预后具有积极作用.
Abstract
Objective:To investigate the effect of plasma exchange(PE)combined with double plasma mo-lecular absorber system(DPMAS)artificial liver mode in patients with acute hepatic failure(AHF).Methods:A total of 80 patients with AHF from January 2019 to January 2022 were randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with PE artificial liver mode,and the observation group was treated with DPMAS artificial liv-er mode.The patients were followed up for three months.The changes in blood routine,coagulation function,and liver and kidney function were compared between the two groups.The basic clinical in-dexes and prognosis were observed.The incidence of related complications during treatment was counted.Results:The blood routine,coagulation function,liver and kidney function,and prognosis of the observation group were significantly better than that of the control group(P＜0.05).The basic clinical indexes of the observation group were lower than those in the control group(P＜0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion:PE+DPMAS artificial liver support system has a positive effect on the treatment of AHF,which can improve coagulation,liver and kidney function,and prognosis.
关键词
急性肝功能衰竭/血浆置换/双重血浆分子吸附/人工肝Key words
Acute Hepatic Failure/Plasma Exchange/Double Plasma Molecular Adsorption/Artificial Liver引用本文复制引用
基金项目
武汉市卫生健康委员会资助项目(WX20C27)
出版年
2024
NETL
NSTL
万方数据