Objective:To investigate the potential causal relationship between chronic obstructive pulmo-nary disease(COPD)and the risk of atrial fibrillation/flutter by using a two-sample Mendelian random-ization(MR)approach.Methods:The study data were obtained from summary statistics of genome-wide association studies(GWAS),with 3 871 COPD cases and 5 669 atrial fibrillation/flutter cases included.A total of seventeen genetic variants that are closely associated with COPD were se-lected as instrumental variables.MR analysis was carried out by inverse variance weighted,weighted median,and MR-Egger methods,respectively.MR-Egger test was used to detect horizontal pleiotro-py,and the leave-one-out sensitivity analysis was conducted to ensure result robustness.Results:The inverse variance weighted analysis showed a significant positive correlation between COPD and the risk of atrial fibrillation/flutter(OR=1.227,95％CI:1.024-1.470,P=0.027).The weighted medi-an method produced similar results(OR=1.209,95％CI:1.008-1.450,P=0.041).In the sensitivi-ty analysis,the MR-Egger test with a P-value of 0.65 suggests the absence of horizontal pleiotropy.Furthermore,the Leave-one-out analysis did not identify any influential SNPs significantly affecting the results.Conclusion:This study suggests that there may be a positive causal relationship between COPD and the risk of atrial fibrillation/flutter.
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万方数据
