Combined heart-kidney transplantation has become an important treatment for patients with end-stage heart disease combined with renal failure in recent years,but there is still a lack of perfect standards for the implementation of combined heart-kidney transplantation in clinic.In this paper,the latest clinical and basic research progress of combined heart-kidney transplantation in China and abroad were reviewed,and the current experience in indications,surgical methods,perioperative management,immunosuppressive methods,prognosis and immunosuppressive mechanism of combined heart-kidney transplantation were summarized to provide a reference for the development and application of combined heart-kidney transplantation.With the deepening understanding on the application specifications of combined heart-kidney transplantation and immunosuppressive mechanism,the survival rate of patients who meet the indications of combined heart-kidney transplantation is often higher than that of patients who receive heart transplantation alone.At the same time,the incidence of rejection is lower than that of heart transplantation alone.However,the indication specifications of combined heart-kidney transplantation are still imperfect and need further study.
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