Expression and clinical significance of LEF1 and TUBB2B in ovarian cancer
Objective:To investigate the expression of LEF1 and TUBB2B in ovarian cancer tissues and their relationship with clinicopathological features.Methods:Multiplex fluorescence immunohisto-chemistry was used to detect the expression of LEF1 and TUBB2B in ovarian cancer tissues of 143 cases.Results:The expression level of LEF1 in recurrent ovarian tissues(3.55±1.99)was signifi-cantly higher than that in non-recurrent ovarian cancer tissues(2.90±1.49),and the difference was statistically significant(P=0.035).However,there was no correlation between the expression of LEF1 and the age of the patients,FIGO staging,tumor size,lymph node positivity,and distant me-tastases.There was no correlation between the expression of TUBB2B and clinicopathologic features mentioned above in ovarian cancer patients.But TUBB2B expression was positively correlated with LEF1 expression(r2=0.852,P<0.000 1).Conclusion:There is a correlation between the expres-sion of LEF1 and TUBB2B in ovarian cancer,and both indicators may work together to promote the development of ovarian cancer.
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